Mutations and Brian Charlesworth

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Profile of Brian Charlesworth.

National Academy of Sciences foreign associate Brian Charlesworth has been at the forefront of evolutionary genetics research for the last four decades. Using theoretical ideas to design experiments and experimental data as a stimulant for the development of theory, Charlesworth investigates fundamental life processes. His work has contributed to improved understanding of molecular evolution an...

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Deborah Charlesworth

too long. It generates a cascade of subtle errors that ultimately accumulate to a distorted picture of the man and his science and indeed early Victorian scientific communities. A varied and overwhelming array of evidence demonstrates that Darwin did not avoid publishing his theory for 20 years.” The only evidence that has ever been put forward for Darwin’s delay is circumstantial or ambiguous ...

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Genetics of a Pheromonal Difference Affecting Sexual Isolation Between Drosophila mauritianu and D . sechellia Jerry A . Coyne and Brian Charlesworth

Females of the sibling species Drosophila sechellia and D. mauritiana differ in their cuticular hydrocarbons: the predominant compound in D. sechellia is 7,ll-heptacosadiene (7,11-HD), while that in D. mauritiana is 7-tricosene (7-T) . We investigate the genetic basis of this difference and its involvement in reproductive isolation between the species. Behavioral studies involving hydrocarbon t...

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Unravelling the evolutionary advantage of sex: a commentary on 'Mutation-selection balance and the evolutionary advantage of sex and recombination' by Brian Charlesworth.

Delving into the literature on the evolution of sex is like picking up a dusty, old, unpromising book and discovering that a fascinating mystery novel lies within it. What makes this tome unpromising is that explaining the evolution of sex seems so trivial at first. Isn't it obvious that sex generates variation ? The fact that nearly all eukaryotes engage in sex, at least occasionally , reinfor...

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And Brian

The I region of the mouse H-2 complex is divided into subregions, I-A, I-B, I-J, I-E, and I-C, that are marked by the Ia-1, Ia-2, Ia-4, Ia-5, and Ia-3 loci, respectively (1, 2). The Ia-1, Ia-5, and Ia-3 locus structural products are Ia antigens, a group of polymorphic, cell-surface glycoproteins that consist of two noncovalently associated polypeptide chains of mol wt =30,000-35,000 (a-subunit)...

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ژورنال

عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences

سال: 2010

ISSN: 0962-8436,1471-2970

DOI: 10.1098/rstb.2009.0319